Resveratrol Prevents Cardiovascular Complications in the SHR/STZ Rat by Reductions in Oxidative Stress and Inflammation
Table 2
Left ventricular pump function and microelectrode parameters following resveratrol administration to control (WKY + Res) and diabetic rats (STZ + Res).
Parameter
WKY
WKY + Res
SHR/STZ
SHR/STZ + Res
Diastolic stiffness
23.7 ± 0.7
22.9 ± 0.9
+dP/dTmax (mmHg/sec)
2025 ± 115
2256 ± 138
−dP/dTmax (mmHg/sec)
−1206 ± 97
−1394 ± 118
−
−
Developed pressure (mmHg)
112.6 ± 5.6
124.0 ± 7.4
103.8 ± 8.6
End systolic pressure (mmHg)
120.0 ± 6.2
134.1 ± 7.2
96.2 ± 11.7
114.8 ± 9.1
Action potential duration at 20% of repolarisation (msec)
18.7 ± 0.9
20.6 ± 0.7
Action potential duration at 50% of repolarisation (msec)
28.7 ± 1.2
31.2 ± 1.4
Action potential duration at 90% of repolarisation (msec)
58.8 ± 3.2
66.7 ± 6.1
Resting membrane potential (mV)
−65.0 ± 2.1
−67.1 ± 1.7
−59.1 ± 2.0
−61.1 ± 3.0
Force of contraction (mN)
2.6 ± 0.7
2.7 ± 0.4
1.7 ± 0.3
1.8 ± 0.3
Values are presented as mean ± SEM. versus WKY, versus SHR/STZ.
