Research Article

-Profiles: A Nonlinear Clustering Method for Pattern Detection in High Dimensional Data

Table 1

Biological pathways significantly associated with clusters 2, 5, 7, and 12.

Cluster# genesGO Biological Process ID valueName of GO term

2228GO:0051301Cell division
GO:0006468Protein phosphorylation
GO:0010696Positive regulation of spindle pole body separation
GO:0030473Nuclear migration along microtubule
GO:0005977Glycogen metabolic process

5116GO:0006301Postreplication repair
GO:0043570Maintenance of DNA repeat elements
GO:0006272Leading strand elongation
GO:0000070Mitotic sister chromatid segregation
GO:0009263Deoxyribonucleotide biosynthetic process
GO:0006298Mismatch repair
GO:0007131Reciprocal meiotic recombination
GO:0045132Meiotic chromosome segregation
GO:0006284Base-excision repair
GO:0006273Lagging strand elongation
GO:0006348Chromatin silencing at telomere
GO:0009200Deoxyribonucleoside triphosphate metabolic process
GO:0051301Cell division

769GO:0006334Nucleosome assembly
GO:0030473Nuclear migration along microtubule
GO:0030148Sphingolipid biosynthetic process
GO:0000032Cell wall mannoprotein biosynthetic process
GO:0009225Nucleotide-sugar metabolic process

12155GO:0007020Microtubule nucleation
GO:0000070Mitotic sister chromatid segregation
GO:0006284Base-excision repair
GO:0006493Protein O-linked glycosylation
GO:0006273Lagging strand elongation
GO:0006337Nucleosome disassembly
GO:0000724Double-strand break repair via homologous recombination
GO:0000086G2/M transition of mitotic cell cycle
GO:0006368Transcription elongation from RNA polymerase II promoter
GO:0006338Chromatin remodeling
GO:0008156Negative regulation of DNA replication

Total number of GO Biological Process terms under study: 430.
value threshold: 0.01.