Nanostructures Control the Hepatocellular Responses to a Cytotoxic Agent “Cisplatin”

<div>Morphological alteration induced by culturing HepG2 cells over grating nanopattern (a) and flat (b) substrate with 0.5 mm cisplatin concentration and grating nanopattern (c) and flat (d) substrate with 0.75 mm cisplatin (for fluorescent micrographs’ scale bar = 20 <i>μ</i>m). The formations of excessive cytoplasmic extensions and irregularities were observed with actin rearrangements followed by subsequent cellular misalignment to the nanogratings at higher concentrations of cisplatin (0.75 mM). Double arrows represent the directions of the grating nanopattern, and arrows show blebs formed as a result of apoptosis.</div>

BioMed Research International

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Figure 4

Figure 4: Nanostructures Control the Hepatocellular Responses to a Cytotoxic Agent “Cisplatin” 