Biologic Roles of Estrogen Receptor-β and Insulin-Like Growth Factor-2 in Triple-Negative Breast Cancer

Figure 2

ERβ1 expression reduces overall survival (OS) in TNBC. TNBCs from 3 African American and 11 Caucasian women were scored for nuclear ERβ1 using IHC with validated antibody (see Table 2). Allred scores >2 are denoted as positive. In this group of patients with advanced TNBC, overall survival (OS) was significantly worse for TNBC patients with high nuclear ERβ1 (positive) as compared to those with low (negative) ERβ1 (). We noted that TNBCs from all 3 African American women were ERβ1-positive.