Hepatoprotective and Antiviral Efficacy of Acacia mellifera Leaves Fractions against Hepatitis B Virus

Table 1

In vivo effect of A. mellifera (AM) crude ethanolic extract on CCl₄-induced hepatotoxicity-related parameters.

Treatment group	Dose mg/kg	AST (U/L)	ALT (U/L)	GGT (U/L)	ALP (U/L)	Bilirubin (mg/dL)
Normal		106.15 ± 4.36	37.91 ± 1.61	3.26 ± 0.21	308.83 ± 8.81	0.5 ± 0.02
CCl4	1.25	379.83 ± 11.70^***a	303.83 ± 12.12^***a	18.20 ± 0.89^***a	586.16 ± 11.92^***a	2.74 ± 0.1^***a
AM + CCl4	250	322.50 ± 12.08^**b	264.83 ± 10.74^*b	12.41 ± 0.73^***b	512.0 ± 11.40^**b	1.66 ± 0.10^***b
AM + CCl4	500	283.66 ± 9.82^***b	178.16 ± 6.27^***	6.90 ± 0.38^***b	398.50 ± 0.48^***b	1.16 ± 0.10^***b
Silymarin + CCl4	10	166.16 ± 9.34^b	99.75 ± 3.55^***	5.78 ± 0.26^***b	325 ± 33 ± 12.10^**b	0.94 ± 0.04^**b

All values represent mean ± SEM. ^*; ^**; ^***; ANOVA, followed by Dunnett’s multiple comparison test. ^aAs compared with normal group. ^bAs compared with CCl₄ only group.