Hepatoprotective and Antiviral Efficacy of Acacia mellifera Leaves Fractions against Hepatitis B Virus
Table 1
In vivo effect of A. mellifera (AM) crude ethanolic extract on CCl4-induced hepatotoxicity-related parameters.
Treatment group
Dose mg/kg
AST (U/L)
ALT (U/L)
GGT (U/L)
ALP (U/L)
Bilirubin (mg/dL)
Normal
106.15 ± 4.36
37.91 ± 1.61
3.26 ± 0.21
308.83 ± 8.81
0.5 ± 0.02
CCl4
1.25
379.83 ± 11.70***a
303.83 ± 12.12***a
18.20 ± 0.89***a
586.16 ± 11.92***a
2.74 ± 0.1***a
AM + CCl4
250
322.50 ± 12.08**b
264.83 ± 10.74*b
12.41 ± 0.73***b
512.0 ± 11.40**b
1.66 ± 0.10***b
AM + CCl4
500
283.66 ± 9.82***b
178.16 ± 6.27***
6.90 ± 0.38***b
398.50 ± 0.48***b
1.16 ± 0.10***b
Silymarin + CCl4
10
166.16 ± 9.34b
99.75 ± 3.55***
5.78 ± 0.26***b
325 ± 33 ± 12.10**b
0.94 ± 0.04**b
All values represent mean ± SEM. *; **; ***; ANOVA, followed by Dunnett’s multiple comparison test. aAs compared with normal group. bAs compared with CCl4 only group.