Minocycline Protection of Neomycin Induced Hearing Loss in Gerbils

Figure 4

Presence of different cell types was scored in the organ of Corti for each minocycline concentration left ear treatment group in three cochlear turns. Ten sections for each cochlear turn were evaluated for each of three animals per treatment (0 mg/kg. 1.2 mg/kg, 1.5 mg/kg minocycline with neomycin) and no neomycin or minocycline control, such that each turn is represented by a total of 30 sections. The percent of sections where each cell type was present and the corresponding cochlear turns (upper basal UB, middle M, and upper middle UM) are indicated. Error bars represent standard deviation of the proportion of sections where the cell type is present, an absent error bar indicates that all sections contained the cell type. (a) shows percent inner hair cells (IHC) present and (b), (c), and (d) show percent outer hair cell (OHC) rows 1, 2, and 3 present, respectively. Dieters cell rows 1, 2, and 3 showed a similar pattern to the outer hair cells (not shown).

(a) Inner hair cells and treatment

(b) Outer hair cell row 1 and treatment

(c) Outer hair cell row 2 and treatment

(d) Outer hair cell row 3 and treatment