Minocycline Protection of Neomycin Induced Hearing Loss in Gerbils

Table 1

Shown are the numbers of animals falling within a given ABR threshold shift bin range over 6–19 kHz test range for each minocycline concentration treatment. See Figure 1 representation of threshold shifts for each treatment over the frequency range tested in the ABRs. Fisher’s exact statistical test tables for threshold shift bin ranges for pairwise combination difference tests among 0 mg/kg, 1.2 mg/kg, and 1.5 mg/kg minocycline treatments were performed on animal numbers. Threshold shifts of 1.2 mg/kg and 1.5 mg/kg minocycline treated animals were not significantly different from each other but were significantly less than threshold shifts of the 0 mg/kg animals ( = 0.028 one sided).

Threshold shift bin range (dB SPL)	Number of animals (0 mg/kg)	Number of animals (1.2 mg/kg)	Number of animals (1.5 mg/kg)
1–19	0	5	3
20 and >20	6	3	3