Histamine Induces Alzheimer’s Disease-Like Blood Brain Barrier Breach and Local Cellular Responses in Mouse Brain Organotypic Cultures

Figure 5

Histamine signaling through different receptor types converges at cellular calcium levels. The four major types of histamine receptors interact with different Gα proteins as indicated. The subsequent steps in the signaling pathway are variable. However, one common feature is that they all affect cellular calcium levels.