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BioMed Research International
Volume 2015 (2015), Article ID 943694, 9 pages
http://dx.doi.org/10.1155/2015/943694
Research Article

Manifestation of Hyperandrogenism in the Continuous Light Exposure-Induced PCOS Rat Model

1College of Acupuncture and Moxibustion, Shanghai University of Traditional Chinese Medicine, Shanghai 201203, China
2Shanghai Research Center for Acupuncture and Meridians, Shanghai 201203, China
3Department of Traditional Chinese Medicine, Huadong Hospital, Fudan University, Shanghai 200040, China

Received 18 September 2014; Accepted 25 November 2014

Academic Editor: Oreste Gualillo

Copyright © 2015 Xuezhi Kang et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Abstract

Polycystic ovary syndrome (PCOS) is a complex endocrine and metabolic disorder, and its pathogenesis has yet to be completely clarified. A fully convincing animal model has not been established for PCOS. In earlier studies, researchers have shown that the exposure of rats to continuous light can induce PCOS; nevertheless, hyperandrogenism, a key characteristic observed in human PCOS, has not been reported previously. In the present study, we found that (1) body weights decreased in female rats in a continuous light environment with both ovarian and uterine augmentation; (2) the estrous cycle in rats under continuous light environment was disordered, and polycystic ovary-like changes occurred, accompanied with fur loss and lethargy; and (3) serum testosterone levels in rats in a continuous light environment significantly increased. Our data suggest that continuous light can lead to the occurrence of PCOS in female rats without the need for drugs; this is a reasonable PCOS animal model that is more consistent with the natural disease state in humans; and poor sleep habits or negligence of sleep hygiene may be an important lifestyle factor in pathogenesis of PCOS.