Transcriptional Changes Associated with Long-Term Left Ventricle Volume Overload in Rats: Impact on Enzymes Related to Myocardial Energy Metabolism

Figure 4

Summary of the observations related to myocardial FAO in the AR rat model made in this study. Soon after AR induction, FAO seems to be increased even before LV dilation has taken place. Then, FAO becomes downregulated as eccentric LVH develops. During the compensated phase of the disease, FAO is relatively stable although FAO genes are downregulated. Later in the disease, LV dilation is even more important. This is accompanied with a general decrease in fatty acids utilization by the heart. See Section 4 for additional information. F: fenofibrate. Nd: not determined.