Transcriptional Changes Associated with Long-Term Left Ventricle Volume Overload in Rats: Impact on Enzymes Related to Myocardial Energy Metabolism

Table 2

Heart remodeling and hemodynamics at 9 months.

Parameters	Sham ()	AR ()	value
Ind heart, mg/mm	21.3 ± 2.7	40.1 ± 1.6	<0.0001
SAP, mm Hg	120 ± 4.0	120 ± 3.3	0.84
DAP, mm Hg	90 ± 4.6	64 ± 2.0	<0.0001
PP, mm Hg	30 ± 2.1	56 ± 2.4	<0.0001
MAP, mm Hg	99 ± 4.3	83 ± 2.5	0.007
, mm Hg/sec	−5994 ± 327	−3871 ± 143	<0.0001
, mm Hg/sec	7483 ± 328	5657 ± 277	<0.0001
LVEDP, mm Hg	9.6 ± 1.6	14.4 ± 1.4	0.044

Measurements obtained under inhaled 1.5% isoflurane anesthesia in surviving animals. Ind heart: indexation was made using tibial length; SAP: systolic arterial pressure; DAP: diastolic arterial pressure; PP: pulse pressure (SAP-DAP); MAP: mean arterial pressure; : minimal derivative of pressure/time; : maximal derivative of pressure/time; LVEDP: left ventricular end-diastolic pressure. Values are mean ± SEM of the indicated number of animals with the exception of and LVEDP values ().