Is Vitamin D Deficiency Related to Accumulation of Advanced Glycation End Products, Markers of Inflammation, and Oxidative Stress in Diabetic Subjects?

Table 2

Multiple regression, effect of ageing, and presence/absence of DM on selected independent variables.

	25(OH)D	HbA1c	AGE-Fl	CML	SAF	sVAP-1	sRAGE	hsCRP	Grips
Corr. m.	0.84	0.001	0.001	0.93	0.001	0.045	0.019	0.001	0.001
Intercept	0.001	0.001	0.001	0.001	0.001	0.001	0.002	0.011	0.001
Age	0.83	0.06	0.001	0.90	0.001	0.23	0.006	0.002	0.001
DM st.	0.62	0.001	0.001	0.69	0.001	0.10	0.20	0.007	0.94
	−0.01	0.35	0.15	−0.01	0.31	0.01	0.03	0.05	0.17

25(OH)D: 25(OH)D₃; HbA1c: haemoglobin A1c; AGE-Fl: advanced glycation end products associated fluorescence of plasma; CML: N^ε-carboxymethyllysine; SAF: skin autofluorescence; sVAP-1: soluble vascular receptor adhesion protein-1; sRAGE: soluble receptor for advanced glycation end products; hsCRP: high sensitive C-reactive protein; corr. M.: corrected model; DM st.: diabetic status, classified 0/1 as absence/presence; italics: due to not normal distribution statistics performed on logarithmically transformed data. In case of sVAP-1, sRAGE, and hsCRP model was significant although age and presence of diabetes explained <5% in their variability ().