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BioMed Research International
Volume 2015, Article ID 958207, 12 pages
http://dx.doi.org/10.1155/2015/958207
Review Article

The G Allele of CaSR R990G Polymorphism Increases Susceptibility to Urolithiasis and Hypercalciuria: Evidences from a Comprehensive Meta-Analysis

Department of Urology, The First Affiliated Hospital of Nanjing Medical University, Nanjing 210029, China

Received 8 August 2014; Revised 4 October 2014; Accepted 6 October 2014

Academic Editor: Mohammad I. Kamboh

Copyright © 2015 Kang Liu et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Linked References

  1. P. C. Damasio, C. R. Amaro, C. R. Padovani et al., “Influence of clinical therapy and nutritional counseling on the recurrence of urolithiasis,” Acta Cirurgica Brasileira, vol. 29, no. 6, pp. 400–404, 2014. View at Google Scholar
  2. D. Li, J. Liu, J. Ren, L. Yan, H. Liu, and Z. Xu, “Meta-analysis of the urokinase gene 3′-UTR T/C polymorphism and susceptibility to urolithiasis,” Bioscience Reports, vol. 1, no. 3, pp. 369–374, 2013. View at Google Scholar
  3. E. M. Worcester and F. L. Coe, “Calcium kidney stones,” The New England Journal of Medicine, vol. 363, no. 10, pp. 954–963, 2010. View at Publisher · View at Google Scholar · View at Scopus
  4. C. J. Danpure and C. J. Danpure, “Genetic disorders and urolithiasis,” Urologic Clinics of North America, vol. 27, no. 2, pp. 287–299, 2000. View at Publisher · View at Google Scholar · View at Scopus
  5. J.-Y. Kim, Y.-S. Kim, I.-H. Jang, J.-D. Jung, T.-H. Kim, and H.-R. Kim, “Interleukin-1β, calcium-Sensing receptor, and urokinase gene polymorphisms in Korean patients with urolithiasis,” Korean Journal of Urology, vol. 52, no. 5, pp. 340–344, 2011. View at Publisher · View at Google Scholar · View at Scopus
  6. S. Wang, X. Wang, J. Wu et al., “Association of vitamin D receptor gene polymorphism and calcium urolithiasis in the Chinese Han population,” Urological Research, vol. 40, no. 4, pp. 277–284, 2012. View at Publisher · View at Google Scholar · View at Scopus
  7. Y.-H. Chou, P. Y. Woon, W.-C. Chen et al., “A genetic polymorphism (rs17251221) in the calcium-sensing receptor gene (CASR) is associated with stone multiplicity in calcium nephrolithiasis,” PLoS ONE, vol. 6, no. 9, Article ID e25227, 2011. View at Publisher · View at Google Scholar · View at Scopus
  8. E. M. Brown and R. J. Macleod, “Extracellular calcium sensing and extracellular calcium signaling,” Physiological Reviews, vol. 81, no. 1, pp. 239–297, 2001. View at Google Scholar · View at Scopus
  9. S. Pidasheva, M. Grant, L. Canaff, O. Ercan, U. Kumar, and G. N. Hendy, “Calcium-sensing receptor dimerizes in the endoplasmic reticulum: biochemical and biophysical characterization of CASR mutants retained intracellularly,” Human Molecular Genetics, vol. 15, no. 14, pp. 2200–2209, 2006. View at Publisher · View at Google Scholar · View at Scopus
  10. G. Vezzoli, A. Terranegra, and L. Soldati, “Calcium-sensing receptor gene polymorphisms in patients with calcium nephrolithiasis,” Current Opinion in Nephrology and Hypertension, vol. 21, no. 4, pp. 355–361, 2012. View at Publisher · View at Google Scholar · View at Scopus
  11. G. Vezzoli, A. Terranegra, T. Arcidiacono et al., “Calcium kidney stones are associated with a haplotype of the calcium-sensing receptor gene regulatory region,” Nephrology Dialysis Transplantation, vol. 25, no. 7, pp. 2245–2252, 2010. View at Publisher · View at Google Scholar · View at Scopus
  12. A. Scillitani, V. Guarnieri, S. De Geronimo et al., “Blood ionized calcium is associated with clustered polymorphisms in the carboxyl-terminal tail of the calcium-sensing receptor,” Journal of Clinical Endocrinology and Metabolism, vol. 89, no. 11, pp. 5634–5638, 2004. View at Publisher · View at Google Scholar · View at Scopus
  13. N. Shakhssalim, B. Kazemi, A. Basiri et al., “Association between calcium-sensing receptor gene polymorphisms and recurrent calcium kidney stone disease: a comprehensive gene analysis,” Scandinavian Journal of Urology and Nephrology, vol. 44, no. 6, pp. 406–412, 2010. View at Publisher · View at Google Scholar · View at Scopus
  14. G. Vezzoli, A. Tanini, L. Ferrucci et al., “Influence of calcium-sensing receptor gene on urinary calcium excretion in stone-forming patients,” Journal of the American Society of Nephrology, vol. 13, no. 10, pp. 2517–2523, 2002. View at Publisher · View at Google Scholar · View at Scopus
  15. G. Han, O. Wang, M. Nie et al., “Clinical phenotypes of Chinese primary hyperparathyroidism patients are associated with the calcium-sensing receptor gene R990G polymorphism,” European Journal of Endocrinology, vol. 169, no. 5, pp. 629–638, 2013. View at Publisher · View at Google Scholar · View at Scopus
  16. D. C. Hamilton, V. K. Grover, C. A. Smith, and D. E. C. Cole, “Heterogeneous disease modeling for Hardy-Weinberg disequilibrium in case-control studies: application to renal stones and calcium-sensing receptor polymorphisms,” Annals of Human Genetics, vol. 73, no. 2, pp. 176–183, 2009. View at Publisher · View at Google Scholar · View at Scopus
  17. A. Scillitani, V. Guarnieri, C. Battista et al., “Primary hyperparathyroidism and the presence of kidney stones are associated with different haplotypes of the calcium-sensing receptor,” Journal of Clinical Endocrinology and Metabolism, vol. 92, no. 1, pp. 277–283, 2007. View at Publisher · View at Google Scholar · View at Scopus
  18. S. Corbetta, C. Eller-Vainicher, M. Filopanti et al., “R990G polymorphism of the calcium-sensing receptor and renal calcium excretion in patients with primary hyperparathyroidism,” European Journal of Endocrinology, vol. 155, no. 5, pp. 687–692, 2006. View at Publisher · View at Google Scholar · View at Scopus
  19. L. G. Ferreira, A. C. Pereira, and I. P. Heilberg, “Vitamin D receptor and calcium-sensing receptor gene polymorphisms in hypercalciuric stone-forming patients,” Nephron: Clinical Practice, vol. 114, no. 2, pp. c135–c144, 2010. View at Publisher · View at Google Scholar · View at Scopus
  20. G. Vezzoli, A. Terranegra, T. Arcidiacono et al., “R990G polymorphism of calcium-sensing receptor does produce a gain-of-function and predispose to primary hypercalciuria,” Kidney International, vol. 71, no. 11, pp. 1155–1162, 2007. View at Publisher · View at Google Scholar · View at Scopus
  21. J. L. Pérez-Castrillón, A. Sanz, J. Silva, I. Justo, E. Velasco, and A. Dueñas, “Calcium-sensing receptor gene A986S polymorphism and bone mass in hypertensive women,” Archives of Medical Research, vol. 37, no. 5, pp. 607–611, 2006. View at Publisher · View at Google Scholar · View at Scopus
  22. B. Harding, A. J. Curley, F. M. Hannan et al., “Functional characterization of calcium sensing receptor polymorphisms and absence of association with indices of calcium homeostasis and bone mineral density,” Clinical Endocrinology, vol. 65, no. 5, pp. 598–605, 2006. View at Publisher · View at Google Scholar · View at Scopus
  23. C. Kelly, I. R. Gunn, D. Gaffney, and M. S. Devgun, “Serum calcium, urine calcium and polymorphisms of the calcium sensing receptor gene,” Annals of Clinical Biochemistry, vol. 43, no. 6, pp. 503–506, 2006. View at Publisher · View at Google Scholar · View at Scopus
  24. H. S. Sacks, J. Berrier, D. Reitman, V. A. Ancona-Berk, and T. C. Chalmers, “Meta-analyses of randomized controlled trials,” New England Journal of Medicine, vol. 316, no. 8, pp. 450–455, 1987. View at Publisher · View at Google Scholar · View at Scopus
  25. R. D. Mittal, H. K. Bid, P. K. Manchanda, and R. Kapoor, “Predisposition of genetic polymorphism with the risk of urolithiasis,” Indian Journal of Clinical Biochemistry, vol. 23, no. 2, pp. 106–116, 2008. View at Publisher · View at Google Scholar · View at Scopus
  26. T. Arcidiacono, A. Terranegra, R. Biasion, L. Soldati, and G. Vezzoli, “Calcium kidney stones. Diagnostic and preventive prospects,” Giornale Italiano di Nefrologia: Organo Ufficiale Della Società Italiana di Nefrologia, vol. 24, no. 6, pp. 535–546, 2007. View at Google Scholar · View at Scopus
  27. G. Vezzoli, A. Terranegra, F. Rainone et al., “Calcium-sensing receptor and calcium kidney stones,” Journal of Translational Medicine, vol. 9, no. 1, article 201, 2011. View at Publisher · View at Google Scholar · View at Scopus
  28. M. R. Munafò and J. Flint, “Meta-analysis of genetic association studies,” Trends in Genetics, vol. 20, no. 9, pp. 439–444, 2004. View at Publisher · View at Google Scholar · View at Scopus
  29. D. Riccardi, A. E. Hall, N. Chattopadhyay et al., “Localization of the extracellular Ca2+/polyvalent cation -sensing protein in rat kidney,” The American Journal of Physiology-Renal Physiology, vol. 274, no. 3, pp. F611–F622, 1998. View at Google Scholar
  30. O. Devuyst and Y. Pirson, “Genetics of hypercalciuric stone forming diseases,” Kidney International, vol. 72, no. 9, pp. 1065–1072, 2007. View at Publisher · View at Google Scholar · View at Scopus
  31. G. Vezzoli, L. Soldati, and G. Gambaro, “Roles of calcium-sensing receptor (CaSR) in renal mineral ion transport,” Current Pharmaceutical Biotechnology, vol. 10, no. 3, pp. 302–310, 2009. View at Publisher · View at Google Scholar · View at Scopus
  32. A. P. Evan, J. E. Lingeman, F. L. Coe et al., “Crystal-associated nephropathy in patients with brushite nephrolithiasis,” Kidney International, vol. 67, no. 2, pp. 576–591, 2005. View at Publisher · View at Google Scholar · View at Scopus
  33. K. Y. Renkema, A. Velic, H. B. Dijkman et al., “The calcium-sensing receptor promotes urinary acidification to prevent nephrolithiasis,” Journal of the American Society of Nephrology, vol. 20, no. 8, pp. 1705–1713, 2009. View at Publisher · View at Google Scholar · View at Scopus
  34. F. Cetani, S. Borsari, E. Vignali et al., “Calcium-sensing receptor gene polymorphisms in primary hyperparathyroidism,” Journal of Endocrinological Investigation, vol. 25, no. 7, pp. 614–619, 2002. View at Publisher · View at Google Scholar · View at Scopus
  35. T. Carling, J. Rastad, A. Kindmark, E. Lundgren, S. Ljunghall, and G. Åkerström, “Estrogen receptor gene polymorphism in postmenopausal primary hyperparathyroidism,” Surgery, vol. 122, no. 6, pp. 1101–1106, 1997. View at Publisher · View at Google Scholar · View at Scopus
  36. C. V. Odvina, K. Sakhaee, H. J. Heller et al., “Biochemical characterization of primary hyperparathyroidism with and without kidney stones,” Urological Research, vol. 35, no. 3, pp. 123–128, 2007. View at Publisher · View at Google Scholar · View at Scopus
  37. D. E. C. Cole, V. D. Peltekova, L. A. Rubin et al., “A986S polymorphism of the calcium-sensing receptor and circulating calcium concentrations,” The Lancet, vol. 353, no. 9147, pp. 112–115, 1999. View at Publisher · View at Google Scholar · View at Scopus
  38. J. Tfelt-Hansen and E. M. Brown, “The calcium-sensing receptor in normal physiology and pathophysiology: a review,” Critical Reviews in Clinical Laboratory Sciences, vol. 42, no. 1, pp. 35–70, 2005. View at Publisher · View at Google Scholar · View at Scopus
  39. C. Y. C. Pak, “Medical management of nephrolithiasis,” Journal of Urology, vol. 128, no. 6, pp. 1157–1164, 1982. View at Google Scholar · View at Scopus