The G Allele of CaSR R990G Polymorphism Increases Susceptibility to Urolithiasis and Hypercalciuria: Evidences from a Comprehensive Meta-Analysis

Table 4

Summary of SMD and 95% CI for associations between urine calcium concentration and CaSR polymorphisms.

Polymorphism	Subgroup		Sample size	SMD (95% CI)	value	heterogeneity
A986S	All	9	1670	0.25 (−0.59–1.10)	0.56	<0.0001
	Caucasian populations	6	886	0.31 (−0.87–1.49)	0.605	<0.0001
	Asian populations	2	597	−0.02 (−0.92–0.88)	0.967	0.015
	Urolithiasis patients	3	827	1.00 (−1.32–3.32)	0.397	<0.0001
	Healthy populations	4	600	−0.35 (−1.00–0.29)	0.282	<0.0001
	PHPT patients	2	243	0.31 (−0.05–0.67)	0.093	0.511
R990G	All	6	1049	2.52 (0.12–4.92)	0.039	<0.0001
	Caucasian populations	4	658	3.62 (−0.18–7.42)	0.062	<0.0001
	Urolithiasis patients	2	333	4.00 (−3.00–10.99)	0.263	<0.0001
	Healthy populations	2	431	3.19 (−3.54–9.93)	0.353	<0.0001
Q1011E	All	5	964	−1.19 (−2.52–0.15)	0.081	<0.0001
	Caucasian populations	3	573	−1.99 (−3.74 to −0.24)	0.026	<0.0001
	Urolithiasis patients	2	327	−1.14 (−4.29–2.01)	0.477	<0.0001
	Healthy populations	2	431	−1.63 (−4.11–0.86)	0.201	<0.0001

The number of studies.