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BioMed Research International
Volume 2015, Article ID 962637, 7 pages
http://dx.doi.org/10.1155/2015/962637
Research Article

miR-1322 Binding Sites in Paralogous and Orthologous Genes

National Nanotechnology Laboratory, Al-Farabi Kazakh National University, 71 Al-Farabi, Almaty 050038, Kazakhstan

Received 10 September 2014; Accepted 19 November 2014

Academic Editor: Vassily Lyubetsky

Copyright © 2015 Raigul Niyazova et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Abstract

We searched for 2,563 microRNA (miRNA) binding sites in 17,494 mRNA sequences of human genes. miR-1322 has more than 2,000 binding sites in 1,058 genes with ratio of 85% and more. miR-1322 has 1,889 binding sites in CDSs, 215 binding sites in 5′ UTRs, and 160 binding sites in 3′ UTRs. From two to 28 binding sites have arranged localization with the start position through three nucleotides of each following binding site. The nucleotide sequences of these sites in CDSs encode oligopeptides with the same and/or different amino acid sequences. We found that 33% of the target genes encoded transcription factors. miR-1322 has arranged binding sites in the CDSs of orthologous MAMLD1, MAML2, and MAML3 genes. These sites encode a polyglutamine oligopeptide ranging from six to 47 amino acids in length. The properties of miR-1322 binding sites in orthologous and paralogous target genes are discussed.