Wnt/β-Catenin Signaling Pathway in Skin Carcinogenesis and Therapy

Figure 1

Hair follicle cycling. The initial developmental phase of hair follicle development terminates with catagen and the first telogen, after which repetitive cycles of anagen (the growth phase), catagen (the regression phase), and telogen (the resting phase) occur throughout the life span of the animal. In general, the hair follicle spends most of its time in anagen, but cycle duration varies according to location, gender, age, and species. The bulge is the source of stem cells for the regenerating hair follicle that is responding to signals from the dermal or follicular papilla (FP). ORS: outer root sheath, IRS: inner root sheath, HS: hair shaft, mel: melanin for the hair shaft, HM: hair matrix, BM: basement membrane, SG: sebaceous gland, and APM: arrector pili muscle [8].