TY - JOUR A2 - Tyan, Yu-Chang AU - Zhu, Yingzhong AU - Xiao, Lufei AU - Zhao, Meng AU - Zhou, Jiazheng AU - Zhang, Qiong AU - Wang, Hui AU - Li, Shengli AU - Zhou, Hongping AU - Wu, Jieying AU - Tian, Yupeng PY - 2015 DA - 2015/10/12 TI - A Series of Imidazole Derivatives: Synthesis, Two-Photon Absorption, and Application for Bioimaging SP - 965386 VL - 2015 AB - A new series of D-π-A type imidazole derivatives have been synthesized and characterized. Two corresponding imidazolium salts (iodine and hexafluorophosphate) were prepared from the imidazole compound. Their electron-withdrawing ability can be largely tunable by salt formation reaction or ion exchange. UV-vis absorption and single-photon fluorescence spectra have been systematically investigated in different solvents. The two-photon cross sections δ2PA of the imidazole derivatives are measured by two-photon excited fluorescence (2PEF) method. Compared with those of T-1 (107 GM) and T-3 (96 GM), T-2 (imidazolium iodine salt) has a large two-photon absorption (2PA) cross section value of 276 GM. Furthermore, the cytotoxicity and applications in bioimaging for the imidazole derivatives were carried out. The results showed that T-1 can be used as a lysosomal tracker with high stability and water solubility within pHs of 4–6, while T-2 and T-3 can be used as probes for cell cytoplasm. SN - 2314-6133 UR - https://doi.org/10.1155/2015/965386 DO - 10.1155/2015/965386 JF - BioMed Research International PB - Hindawi Publishing Corporation KW - ER -