A Survival Association Study of 102 Polymorphisms Previously Associated with Survival Outcomes in Colorectal Cancer
Table 2
Results of the univariate and multivariable Cox regression analysis for the SNPs that are nominally associated with overall or disease-free survivals ().
Genetic model
SNP
value
HR
95% CI for HR
value
value
HR
95% CI for HR
value
Lower
Upper
Lower
Upper
OS (univariate)
OS (adjusted for stage)
Dominant
504
IFNGR1_rs1327474 (AG+GG vs AA)
0.003
0.624
0.457
0.853
0.243
0.022
0.691
0.504
0.947
0.351
RRM1_rs12806698
0.02
0.389
0.045
0.456
Codominant
504
RRM1_rs12806698 (CA vs CC)
0.008
1.524
1.116
2.082
0.324
0.015
1.472
1.077
2.011
0.351
RRM1_rs12806698 (AA vs CC)
0.833
0.934
0.497
1.757
0.865
0.941
1.024
0.542
1.935
1
DFS (univariate)
DFS (adjusted for stage)
Additive
503
DDX20_rs197412
0.003
0.714
0.574
0.889
0.159
0.004
0.725
0.581
0.905
0.212
Dominant
503
IFNGR1_rs1327474 (AG+GG vs AA)
0.003
0.642
0.480
0.859
0.159
0.017
0.701
0.524
0.939
0.3
Dominant
503
HSPA5_rs391957 (TC+TT vs CC)
0.011
0.692
0.521
0.918
0.233
0.007
0.676
0.509
0.897
0.247
PTGS2_rs5275
0.023
0.327
0.011
0.254
Codominant
503
PTGS2_rs5275 (TC vs TT)
0.009
1.477
1.100
1.984
0.233
0.004
1.541
1.147
2.071
0.212
PTGS2_rs5275 (CC vs TT)
0.974
1.008
0.617
1.646
0.974
0.872
1.041
0.637
1.702
0.919
CI: confidence interval; DFS: disease-free survival; HR: hazards ratio; : number of patients in the analysis; OS: overall survival; SNP: single nucleotide polymorphism.
