BioMed Research International / 2015 / Article / Tab 2

Research Article

A Survival Association Study of 102 Polymorphisms Previously Associated with Survival Outcomes in Colorectal Cancer

Table 2

Results of the univariate and multivariable Cox regression analysis for the SNPs that are nominally associated with overall or disease-free survivals ().

Genetic model SNP valueHR95% CI for HR value valueHR95% CI for HR value
LowerUpperLowerUpper

OS (univariate)OS (adjusted for stage)
Dominant504IFNGR1_rs1327474 (AG+GG vs AA)0.0030.6240.4570.8530.2430.0220.6910.5040.9470.351
RRM1_rs128066980.020.3890.0450.456
Codominant504RRM1_rs12806698 (CA vs CC)0.0081.5241.1162.0820.3240.0151.4721.0772.0110.351
RRM1_rs12806698 (AA vs CC)0.8330.9340.4971.7570.8650.9411.0240.5421.9351

DFS (univariate)DFS (adjusted for stage)
Additive503DDX20_rs1974120.0030.7140.5740.8890.1590.0040.7250.5810.9050.212
Dominant503IFNGR1_rs1327474 (AG+GG vs AA)0.0030.6420.4800.8590.1590.0170.7010.5240.9390.3
Dominant503HSPA5_rs391957 (TC+TT vs CC)0.0110.6920.5210.9180.2330.0070.6760.5090.8970.247
PTGS2_rs52750.0230.3270.0110.254
Codominant503PTGS2_rs5275 (TC vs TT)0.0091.4771.1001.9840.2330.0041.5411.1472.0710.212
PTGS2_rs5275 (CC vs TT)0.9741.0080.6171.6460.9740.8721.0410.6371.7020.919

CI: confidence interval; DFS: disease-free survival; HR: hazards ratio; : number of patients in the analysis; OS: overall survival; SNP: single nucleotide polymorphism.

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