Table of Contents Author Guidelines Submit a Manuscript
BioMed Research International
Volume 2015, Article ID 968927, 9 pages
http://dx.doi.org/10.1155/2015/968927
Research Article

Epoetin Alpha and Epoetin Zeta: A Comparative Study on Stimulation of Angiogenesis and Wound Repair in an Experimental Model of Burn Injury

1Department of Clinical and Experimental Medicine, University of Messina, 98125 Messina, Italy
2Department of Dentistry and Medical and Surgical Experimental Sciences, University of Messina, 98125 Messina, Italy
3Department of Paediatric, Gynaecological, Microbiological and Biomedical Sciences, University of Messina, 98125 Messina, Italy

Received 19 December 2014; Revised 2 April 2015; Accepted 15 April 2015

Academic Editor: Themis R. Kyriakides

Copyright © 2015 Natasha Irrera et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Linked References

  1. W. Jelkmann, “Biology of erythropoietin,” Clinical Investigator, vol. 72, no. 6, pp. S3–S10, 1994. View at Google Scholar · View at Scopus
  2. M. Piagnerelli and J.-L. Vincent, “The use of erythropoiesis-stimulating agents in the intensive care unit,” Critical Care Clinics, vol. 28, no. 3, pp. 345–362, 2012. View at Publisher · View at Google Scholar · View at Scopus
  3. H. Youssoufian, G. Longmore, D. Neumann, A. Yoshimura, and H. F. Lodish, “Structure, function, and activation of the erythropoietin receptor,” Blood, vol. 81, no. 9, pp. 2223–2236, 1993. View at Google Scholar · View at Scopus
  4. J. Rossert and K.-U. Eckardt, “Erythropoietin receptors: their role beyond erythropoiesis,” Nephrology Dialysis Transplantation, vol. 20, pp. 1025–1028, 2005. View at Publisher · View at Google Scholar · View at Scopus
  5. M. Brines and A. Cerami, “Discovering erythropoietin's extra-hematopoietic functions: biology and clinical promise,” Kidney International, vol. 70, no. 2, pp. 246–250, 2006. View at Publisher · View at Google Scholar · View at Scopus
  6. F. P. Barbone, D. L. Johnson, F. X. Farrell et al., “New epoetin molecules and novel therapeutic approaches,” Nephrology Dialysis Transplantation, vol. 14, no. 2, pp. 80–84, 1999. View at Publisher · View at Google Scholar · View at Scopus
  7. P. J. Connolly, S. K. Wetter, W. V. Murray et al., “Synthesis and erythropoietin receptor binding affinities of N, N-disubstituted amino acids,” Bioorganic and Medicinal Chemistry Letters, vol. 10, no. 17, pp. 1995–1999, 2000. View at Publisher · View at Google Scholar · View at Scopus
  8. Z. A. Haroon, K. Amin, X. Jiang, and M. O. Arcasoy, “A novel role for erythropoietin during fibrin-induced wound-healing response,” American Journal of Pathology, vol. 163, no. 3, pp. 993–1000, 2003. View at Publisher · View at Google Scholar · View at Scopus
  9. D. Ribatti, M. Presta, A. Vacca et al., “Human erythropoietin induces a pro-angiogenic phenotype in cultured endothelial cells and stimulates neovascularization in vivo,” Blood, vol. 93, no. 8, pp. 2627–2636, 1999. View at Google Scholar · View at Scopus
  10. M. Buemi, A. Lacquaniti, D. Bolignano et al., “The erythropoietin and regenerative medicine: a lesson from fish,” European Journal of Clinical Investigation, vol. 39, no. 11, pp. 993–999, 2009. View at Publisher · View at Google Scholar · View at Scopus
  11. M. Galeano, D. Altavilla, D. Cucinotta et al., “Recombinant human erythropoietin stimulates angiogenesis and wound healing in the genetically diabetic mouse,” Diabetes, vol. 53, no. 9, pp. 2509–2517, 2004. View at Publisher · View at Google Scholar · View at Scopus
  12. M. Galeano, D. Altavilla, A. Bitto et al., “Recombinant human erythropoietin improves angiogenesis and wound healing in experimental burn wounds,” Critical Care Medicine, vol. 34, no. 4, pp. 1139–1146, 2006. View at Publisher · View at Google Scholar · View at Scopus
  13. C. Baldamus, S. Krivoshiev, M. Wolf-Pflugmann, M. Siebert-Weigel, R. Koytchev, and A. Bronn, “Long-term safety and tolerability of epoetin zeta, administered intravenously, for maintenance treatment of renal anemia,” Advances in Therapy, vol. 25, no. 11, pp. 1215–1228, 2008. View at Publisher · View at Google Scholar · View at Scopus
  14. V. Wizemann, B. Rutkowski, C. Baldamus, P. Scigalla, and R. Koytchev, “Comparison of the therapeutic effects of epoetin zeta to epoetin alfa in the maintenance phase of renal anemia treatment,” Current Medical Research & Opinion, vol. 24, no. 3, pp. 625–637, 2008. View at Google Scholar
  15. S. Krivoshiev, V. V. Todorov, J. Manitius, S. Czekalski, P. Scigalla, and R. Koytchev, “Comparison of the therapeutic effects of epoetin zeta and epoetin alfa in the correction of renal anaemia,” Current Medical Research and Opinion, vol. 24, no. 5, pp. 1407–1415, 2008. View at Publisher · View at Google Scholar · View at Scopus
  16. T. McGowan, N. M. Vaccaro, J. S. Beaver, J. Massarella, and M. Wolfson, “Pharmacokinetic and pharmacodynamic profiles of extended dosing of epoetin alfa in anemic patients who have chronic kidney disease and are not on dialysis,” Clinical Journal of the American Society of Nephrology, vol. 3, no. 4, pp. 1006–1014, 2008. View at Publisher · View at Google Scholar · View at Scopus
  17. S. D. Roger, “Biosimilars: how similar or dissimilar are they?” Nephrology, vol. 11, no. 4, pp. 341–346, 2006. View at Publisher · View at Google Scholar · View at Scopus
  18. G. Barosi, A. Bosi, M. P. Abbracchio et al., “Key concepts and critical issues on epoetin and filgrastim biosimilars: a position paper from the Italian Society of Hematology, Italian Society of Experimental Hematology, and Italian Group for Bone Marrow Transplantation,” Haematologica, vol. 96, no. 7, pp. 937–942, 2011. View at Publisher · View at Google Scholar · View at Scopus
  19. A. S. Tsiftsoglou, S. Ruiz, and C. K. Schneider, “Development and regulation of biosimilars: current status and future challenges,” BioDrugs, vol. 27, no. 3, pp. 203–211, 2013. View at Publisher · View at Google Scholar · View at Scopus
  20. S. Tamilvanan, N. L. Raja, B. Sa, and S. K. Basu, “Clinical concerns of immunogenicity produced at cellular levels by biopharmaceuticals following their parenteral administration into human body,” Journal of Drug Targeting, vol. 18, no. 7, pp. 489–498, 2010. View at Publisher · View at Google Scholar · View at Scopus
  21. Z. A. Haroon, K. Amin, X. Jiang, and M. O. Arcasoy, “A novel role for erythropoietin during fibrin-induced wound-healing response,” American Journal of Pathology, vol. 163, no. 3, pp. 993–1000, 2003. View at Publisher · View at Google Scholar · View at Scopus
  22. B. M. Kang, S. H. Shin, M. H. Kwack et al., “Erythropoietin promotes hair shaft growth in cultured human hair follicles and modulates hair growth in mice,” Journal of Dermatological Science, vol. 59, no. 2, pp. 86–90, 2010. View at Publisher · View at Google Scholar · View at Scopus
  23. G. H. Bishop, “Regeneration after experimental removal of skin in man,” American Journal of Anatomy, vol. 76, no. 2, pp. 153–181, 1945. View at Publisher · View at Google Scholar
  24. V. Martinot, V. Mitchell, P. Fevrier, A. Duhamel, and P. Pellerin, “Comparative study of split thickness skin grafts taken from the scalp and thigh in children,” Burns, vol. 20, no. 2, pp. 146–150, 1994. View at Publisher · View at Google Scholar · View at Scopus
  25. A. K. Langton, S. E. Herrick, and D. J. Headon, “An extended epidermal response heals cutaneous wounds in the absence of a hair follicle stem cell contribution,” Journal of Investigative Dermatology, vol. 128, no. 5, pp. 1311–1318, 2008. View at Publisher · View at Google Scholar · View at Scopus
  26. M. Ito, Y. Liu, Z. Yang et al., “Stem cells in the hair follicle bulge contribute to wound repair but not to homeostasis of the epidermis,” Nature Medicine, vol. 11, no. 12, pp. 1351–1354, 2005. View at Publisher · View at Google Scholar · View at Scopus
  27. C. A. B. Jahoda and A. J. Reynolds, “Hair follicle dermal sheath cells: unsung participants in wound healing,” The Lancet, vol. 358, no. 9291, pp. 1445–1448, 2001. View at Publisher · View at Google Scholar · View at Scopus
  28. C. I. Günter, A. Bader, U. Dornseifer et al., “A multi-center study on the regenerative effects of erythropoietin in burn and scalding injuries: study protocol for a randomized controlled trial,” Trials, vol. 14, no. 1, article 124, 2013. View at Publisher · View at Google Scholar · View at Scopus
  29. E. Bodó, A. Kromminga, W. Funk et al., “Human hair follicles are an extrarenal source and a nonhematopoietic target of erythropoietin,” The FASEB Journal, vol. 21, no. 12, pp. 3346–3354, 2007. View at Publisher · View at Google Scholar · View at Scopus
  30. M. V. A. Arroyo, M. A. Castilla, F. R. G. Pacheco et al., “Role of vascular endothelial growth factor on erythropoietin-related endothelial cell proliferation,” Journal of the American Society of Nephrology, vol. 9, no. 11, pp. 1998–2004, 1998. View at Google Scholar · View at Scopus
  31. P. Nurse, “A long twentieth century of the cell cycle and beyond,” Cell, vol. 100, no. 1, pp. 71–78, 2000. View at Publisher · View at Google Scholar · View at Scopus
  32. J. Bartkova, B. Grøn, E. Dabelsteen, and J. Bartek, “Cell-cycle regulatory proteins in human wound healing,” Archives of Oral Biology, vol. 48, no. 2, pp. 125–132, 2003. View at Publisher · View at Google Scholar · View at Scopus
  33. H.-S. Peng, X.-H. Xu, R. Zhang et al., “Multiple low doses of erythropoietin delay the proliferation of hepatocytes but promote liver function in a rat model of subtotal hepatectomy,” Surgery Today, vol. 44, no. 6, pp. 1109–1115, 2014. View at Publisher · View at Google Scholar · View at Scopus
  34. H. Sorg, C. Krueger, T. Schulz, M. D. Menger, F. Schmitz, and B. Vollmar, “Effects of erythropoietin in skin wound healing are dose related,” The FASEB Journal, vol. 23, no. 9, pp. 3049–3058, 2009. View at Publisher · View at Google Scholar · View at Scopus
  35. D. Schmauss, F. Rezaeian, T. Finck, H. G. Machens, R. Wettstein, and Y. Harder, “Treatment of secondary burn wound progression in contact burns—a systematic review of experimental approaches,” Journal of Burn Care & Research, 2015. View at Publisher · View at Google Scholar
  36. M. Tobalem, Y. Harder, F. Rezaeian, and R. Wettstein, “Secondary burn progression decreased by erythropoietin,” Critical Care Medicine, vol. 41, no. 4, pp. 963–971, 2013. View at Publisher · View at Google Scholar · View at Scopus
  37. A. Bader, S. Ebert, S. Giri et al., “Skin regeneration with conical and hair follicle structure of deep second-degree scalding injuries via combined expression of the EPO receptor and beta common receptor by local subcutaneous injection of nanosized rhEPO,” International Journal of Nanomedicine, vol. 7, pp. 1227–1237, 2012. View at Publisher · View at Google Scholar · View at Scopus