Curcumin and Its Analogue Induce Apoptosis in Leukemia Cells and Have Additive Effects with Bortezomib in Cellular and Xenograft Models

Table 3

In vitro effect of curcumin and C-150 on NF-κB signaling. Curcumin and its analogue C-150 alone or in coadministration with bortezomib decreased the activation of NF-κB pathway in a dose-dependent manner. Modest significant additive effect was recorded after coadministration of C-150 with bortezomib (: bortezomib versus combination; : curcumin or C-150 versus combination; two-tailed Student’s -test).

	—	BTZ; (50 nM)	BTZ; (12.5 nM)	BTZ; (3.125 nM)	BTZ; (0.78 nM)
—		0.36	0.44	0.54	0.94
C (50 µM)	0.19	0.20	0.22	0.28	0.28
C (25 µM)	0.20	0.24	0.31	0.44	0.34
C (10 µM)	0.43	0.32	0.25	0.47	0.54
C (5 µM)	1.05	0.54	0.61	0.64	0.94
C-150 (1 µM)	0.58	0.37	0.41	0.44; ()	0.65
C-150 (0.5 µM)	0.82	0.36	0.50	0.56	0.72
C-150 (0.1 µM)	1.17	0.32; ()	0.54	0.58	0.79; ()
C-150 (0.05 µM)	0.99	0.38	0.54	0.49; ()	0.95