Acute and Chronic Toxicity, Cytochrome P450 Enzyme Inhibition, and hERG Channel Blockade Studies with a Polyherbal, Ayurvedic Formulation for Inflammation

Table 4

Effect of BV-9238 at a dose of (0.5 g/mL) on six major isoforms of human CYP450 enzymes. Positive control inhibitors were tested in multiple doses and deduced IC50 (50% inhibitory concentration) is given in parenthesis.

	Enzymes tested	% inhibition	Control compound (IC50)
1	CYP450 1A2	4	Furafylline (1.07 M)
2	CYP450 2C19	35	Tranylcypromine (4.28 M)
3	CYP450 2C9	2	Sulfaphenazole (0.418 M)
4	CYP450 2D6	2	Quinidine (0.0345 M)
5	CYP450 2E1	1	4-Methylpyrazole (8.56 M)
6	CYP450 3A4	19	Ketoconazole (0.109 M)