BioMed Research International / 2015 / Article / Tab 4

Research Article

Acute and Chronic Toxicity, Cytochrome P450 Enzyme Inhibition, and hERG Channel Blockade Studies with a Polyherbal, Ayurvedic Formulation for Inflammation

Table 4

Effect of BV-9238 at a dose of (0.5 g/mL) on six major isoforms of human CYP450 enzymes. Positive control inhibitors were tested in multiple doses and deduced IC50 (50% inhibitory concentration) is given in parenthesis.

Enzymes tested% inhibitionControl compound (IC50)

1CYP450 1A24Furafylline (1.07 M)
2CYP450 2C1935Tranylcypromine (4.28 M)
3CYP450 2C92Sulfaphenazole (0.418 M)
4CYP450 2D62Quinidine (0.0345 M)
5CYP450 2E114-Methylpyrazole (8.56 M)
6CYP450 3A419Ketoconazole (0.109 M)

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