Gut Microbiota: Association with NAFLD and Metabolic Disturbances

Figure 1

Schematic view of how the gut microbiota affects host fat storage and insulin resistance, which may result in NAFLD. The microbiota acts through an increase in the transactivation of lipogenic enzymes by liver carbohydrate response element binding protein (ChREBP) and sterol regulatory element binding protein 1 (SREBP-1), an increase in the uptake of dietary polysaccharides and through Fiaf inhibition with increased LPL activity in adipocytes, thereby promoting increase of hepatic lipogenesis and storage of calories harvested from the diet into fat.