BioMed Research International / 2015 / Article / Tab 2

Clinical Study

Long-Term Clinical Outcome after Treatment for High-Grade Cervical Lesions: A Retrospective Monoinstitutional Cohort Study

Table 2

Multivariate logistic regression analyses to identify predictive factors of the risk of residual or recurrent high-grade lesions in 760 women treated for CIN2+ (upper part) and among 506 women without residual high-grade disease at first follow-up visit who had a HPV test (lower part). Only variables that resulted significant after a forward-stepwise selection are reported.

Women treated for CIN2+ ()
Variable Risk of residual or recurrent CIN2 Risk of residual or recurrent CIN3+
Odds ratio
(95% CI)
valueOdds ratio
(95% CI)
value

Histological diagnosis at baseline
 CIN2*1.00
 CIN3+6.02 (1.73–20.9)0.005
Margins status of the excised lesions
 Negative*1.001.00
 Positive5.11 (2.42–10.8)<0.00113.8 (4.98–38.5)<0.001

Women without residual high-grade disease at first follow-up visit with HPV test ()
Variable Risk of recurrent CIN2 Risk of recurrent CIN3
Odds ratio
(95% CI)
valueOdds ratio
(95% CI)
value

Histological diagnosis at baseline
 CIN2*1.00
 CIN3+0.4 (0.12–1.29)0.125
Squamocolumnar junction location
 Type 1*1.00
 Type 21.68 (0.14–20.5)0.68
 Type 327.7 (2.07–369)0.012
Colposcopic diagnosis at baseline
 G1*1.00
 G24.17 (1.28–13.6)0.018
 Negative1.67 (0.37–7.61)0.503
HPV test at first follow-up
 Negative*1.001.00
 HPV 1613.3 (3.48–50.5)<0.00163.6 (4.45–909)0.002
 Other high-risk HPV22.3 (5.69–87.3)<0.0017.76 (0.42–142)0.168
 Low-risk HPV2.94 (0.67–12.8)0.152

Reference.
Adjusted for all the variables in the table.
Nonsignificant, excluded from the model.
No CIN3+ events in the Low-risk group, excluded from the model.