Rapamycin Protects from Type-I Peritoneal Membrane Failure Inhibiting the Angiogenesis, Lymphangiogenesis, and Endo-MT

Figure 7

Rapamycin partially inhibited the MCs protein synthesis and MCs proliferation. (a) Rapamycin inhibits the tubulin expression in a time- and dose-dependent manner as shown in the Western blots analyses and their quantification graphics. Results are presented relative to untreated MCs (black bars) which were arbitrarily assigned as value 1. (b) MCs proliferation and (c) protein synthesis omentum cells cultured in semiconfluence. The first box represents baseline MCs (zero time). Second box shows the natural increases in MCs proliferation and protein synthesis at 48 h. The rest of the boxes show the decrease in both variables after the Rapamycin administration in a dose-dependent manner. In (b) and (c), one-way ANOVA analyses show a value of and , respectively. Box plots represent the median, minimum, and maximum values, as well as the 25th and 75th percentiles.

(a)

(b)

(c)