Molecular Imaging for Comparison of Different Growth Factors on Bone Marrow-Derived Mesenchymal Stromal Cells’ Survival and Proliferation In Vivo

Figure 2

The effects of pretreatment with VEGF, IGF-1, and bFGF on hypoxia-induced apoptosis of bone marrow-derived mesenchymal stromal cells (BMSCs). (a) Apoptosis analysis of BMSCs by flow cytometry; when exposed to hypoxia, BMSCs treated with IGF-1 and bFGF underwent less apoptosis compared with control (% and % versus %; ; in each group), while the apoptosis rate of VEGF was %. (b) Apoptosis analysis of BMSCs by TUNEL assay; BMSCs with bFGF and IGF-1 showed a lower calculated apoptotic rate (% and % versus %, ), while VEGF was %; versus control; in each group. Bar scale = 80 μm.

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