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BioMed Research International
Volume 2016, Article ID 1376526, 12 pages
http://dx.doi.org/10.1155/2016/1376526
Research Article

Comparison of the Effects of Dibutyl and Monobutyl Phthalates on the Steroidogenesis of Rat Immature Leydig Cells

1Center of Scientific Research, The Second Affiliated Hospital & Yuying Children’s Hospital, Wenzhou Medical University, Wenzhou, Zhejiang 325027, China
2Department of Anesthiology, The Second Affiliated Hospital & Yuying Children’s Hospital, Wenzhou Medical University, Wenzhou, Zhejiang 325027, China
3School of Pharmacy, Wenzhou Medical University, Wenzhou, Zhejiang 325035, China
4Taizhou Hospital of Zhejiang Province, Taizhou 317000, China

Received 3 January 2016; Accepted 17 February 2016

Academic Editor: Stelvio M. Bandiera

Copyright © 2016 Linxi Li et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Linked References

  1. B. C. Blount, M. J. Silva, S. P. Caudill et al., “Levels of seven urinary phthalate metabolites in a human reference population,” Environmental Health Perspectives, vol. 108, no. 10, pp. 979–982, 2000. View at Google Scholar · View at Scopus
  2. M. C. Kohn, F. Parham, S. A. Masten et al., “Human exposure estimates for phthalates,” Environmental Health Perspectives, vol. 108, no. 10, pp. A440–A442, 2000. View at Google Scholar · View at Scopus
  3. W.-H. Chang, S.-S. Li, M.-H. Wu, H.-A. Pan, and C.-C. Lee, “Phthalates might interfere with testicular function by reducing testosterone and insulin-like factor 3 levels,” Human Reproduction, vol. 30, no. 11, pp. 2658–2670, 2015. View at Publisher · View at Google Scholar · View at Scopus
  4. M. S. Bloom, B. W. Whitcomb, Z. Chen, A. Ye, K. Kannan, and G. M. Buck Louis, “Associations between urinary phthalate concentrations and semen quality parameters in a general population,” Human Reproduction, vol. 30, no. 11, pp. 2645–2657, 2015. View at Publisher · View at Google Scholar · View at Scopus
  5. G.-X. Hu, Q.-Q. Lian, R.-S. Ge, D. O. Hardy, and X.-K. Li, “Phthalate-induced testicular dysgenesis syndrome: leydig cell influence,” Trends in Endocrinology and Metabolism, vol. 20, no. 3, pp. 139–145, 2009. View at Publisher · View at Google Scholar · View at Scopus
  6. S. van den Driesche, C. McKinnell, A. Calarrão et al., “Comparative effects of di(n-butyl) phthalate exposure on fetal germ cell development in the rat and in human fetal testis xenografts,” Environmental Health Perspectives, vol. 123, no. 3, pp. 223–230, 2015. View at Publisher · View at Google Scholar · View at Scopus
  7. J. R. Rodriguez-Sosa, A. Bondareva, L. Tang et al., “Phthalate esters affect maturation and function of primate testis tissue ectopically grafted in mice,” Molecular and Cellular Endocrinology, vol. 398, no. 1-2, pp. 89–100, 2014. View at Publisher · View at Google Scholar · View at Scopus
  8. U. M. Bello, M. C. Madekurozwa, H. B. Groenewald, T. A. Aire, and A. Arukwe, “The effects on steroidogenesis and histopathology of adult male Japanese quails (Coturnix coturnix japonica) testis following pre-pubertal exposure to di(n-butyl) phthalate (DBP),” Comparative Biochemistry and Physiology Part C: Toxicology & Pharmacology, vol. 166, pp. 24–33, 2014. View at Google Scholar
  9. X. Chen, Q.-H. Zhou, L. Leng, X. Chen, Z.-R. Sun, and N.-J. Tang, “Effects of di(n-butyl) and monobutyl phthalate on steroidogenesis pathways in the murine Leydig tumor cell line MLTC-1,” Environmental Toxicology and Pharmacology, vol. 36, no. 2, pp. 332–338, 2013. View at Publisher · View at Google Scholar · View at Scopus
  10. E. Mylchreest, M. Sar, D. G. Wallace, and P. M. Foster, “Fetal testosterone insufficiency and abnormal proliferation of Leydig cells and gonocytes in rats exposed to di(n-butyl) phthalate,” Reproductive Toxicology, vol. 16, no. 1, pp. 19–28, 2002. View at Publisher · View at Google Scholar
  11. R.-S. Ge, G.-R. Chen, C. Tanrikut, and M. P. Hardy, “Phthalate ester toxicity in Leydig cells: developmental timing and dosage considerations,” Reproductive Toxicology, vol. 23, no. 3, pp. 366–373, 2007. View at Publisher · View at Google Scholar · View at Scopus
  12. H. Chen, R.-S. Ge, and B. R. Zirkin, “Leydig cells: from stem cells to aging,” Molecular and Cellular Endocrinology, vol. 306, no. 1-2, pp. 9–16, 2009. View at Publisher · View at Google Scholar · View at Scopus
  13. R.-S. Ge, Q. Dong, C. M. Sottas, V. Papadopoulos, B. R. Zirkin, and M. P. Hardy, “In search of rat stem Leydig cells: identification, isolation, and lineage-specific development,” Proceedings of the National Academy of Sciences of the United States of America, vol. 103, no. 8, pp. 2719–2724, 2006. View at Publisher · View at Google Scholar · View at Scopus
  14. R.-S. Ge and M. P. Hardy, “Variation in the end products of androgen biosynthesis and metabolism during postnatal differentiation of rat leydig cells,” Endocrinology, vol. 139, no. 9, pp. 3787–3795, 1998. View at Publisher · View at Google Scholar · View at Scopus
  15. R. S. Ge and M. P. Hardy, “Regulation of Leydig cells during pubertal development,” in The Leydig Cell in Health and Disease, A. H. Payne and M. P. Hardy, Eds., pp. 55–70, Humana Press, Totowa, NJ, USA, 2007. View at Google Scholar
  16. A. H. Payne, K. L. Wong, and M. M. Vega, “Differential effects of single and repeated administrations of gonadotropins on luteinizing hormone receptors and testosterone synthesis in two populations of Leydig cells,” The Journal of Biological Chemistry, vol. 255, no. 15, pp. 7118–7122, 1980. View at Google Scholar · View at Scopus
  17. R.-S. Ge, H.-B. Gao, V. L. Nacharaju, G. L. Gunsalus, and M. P. Hardy, “Identification of a kinetically distinct activity of 11beta-hydroxysteroid dehydrogenase in rat leydig cells,” Endocrinology, vol. 138, no. 6, pp. 2435–2442, 1997. View at Publisher · View at Google Scholar · View at Scopus
  18. G.-X. Hu, H.-Y. Zhou, X.-W. Li et al., “The (+)- and (−)-gossypols potently inhibit both 3β-hydroxysteroid dehydrogenase and 17β-hydroxysteroid dehydrogenase 3 in human and rat testes,” Journal of Steroid Biochemistry and Molecular Biology, vol. 115, no. 1-2, pp. 14–19, 2009. View at Publisher · View at Google Scholar · View at Scopus
  19. J. Guo, H. Zhou, Z. Su et al., “Comparison of cell types in the rat Leydig cell lineage after ethane dimethanesulfonate treatment,” Reproduction, vol. 145, no. 4, pp. 371–380, 2013. View at Publisher · View at Google Scholar · View at Scopus
  20. H. Lin, R.-S. Ge, G.-R. Chen et al., “Involvement of testicular growth factors in fetal Leydig cell aggregation after exposure to phthalate in utero,” Proceedings of the National Academy of Sciences of the United States of America, vol. 105, no. 20, pp. 7218–7222, 2008. View at Publisher · View at Google Scholar · View at Scopus
  21. K. Yuan, B. Zhao, X.-W. Li et al., “Effects of phthalates on 3β-hydroxysteroid dehydrogenase and 17β-hydroxysteroid dehydrogenase 3 activities in human and rat testes,” Chemico-Biological Interactions, vol. 195, no. 3, pp. 180–188, 2012. View at Publisher · View at Google Scholar · View at Scopus
  22. R. S. Ge and M. P. Hardy, “Decreased cyclin A2 and increased cyclin G1 levels coincide with loss of proliferative capacity in rat Leydig cells during pubertal development,” Endocrinology, vol. 138, no. 9, pp. 3719–3726, 1997. View at Google Scholar
  23. J. Borch, M. Dalgaard, and O. Ladefoged, “Early testicular effects in rats perinatally exposed to DEHP in combination with DEHA—apoptosis assessment and immunohistochemical studies,” Reproductive Toxicology, vol. 19, no. 4, pp. 517–525, 2005. View at Publisher · View at Google Scholar · View at Scopus
  24. C. R. González, B. González, M. E. Matzkin et al., “Psychostimulant-induced testicular toxicity in mice: evidence of cocaine and caffeine effects on the local dopaminergic system,” PLoS ONE, vol. 10, no. 11, Article ID e0142713, 2015. View at Publisher · View at Google Scholar
  25. K. Svechnikov, I. Savchuk, M. L. Morvan, J. P. Antignac, B. Le Bizec, and O. Soder, “Phthalates exert multiple effects on leydig cell steroidogenesis,” Hormone Research in Paediatrics, 2015. View at Publisher · View at Google Scholar
  26. K. M. Sargent, R. M. McFee, R. S. Gomes, and A. S. Cupp, “Vascular endothelial growth factor A: just one of multiple mechanisms for sex-specific vascular development within the testis?” Journal of Endocrinology, vol. 227, no. 2, pp. R31–R50, 2015. View at Publisher · View at Google Scholar · View at Scopus
  27. P. W. Albro and B. Moore, “Identification of the metabolites of simple phthalate diesters in rat urine,” Journal of Chromatography, vol. 94, pp. 209–218, 1974. View at Google Scholar
  28. Y.-J. Lien, H.-Y. Ku, P.-H. Su et al., “Prenatal exposure to phthalate esters and behavioral syndromes in children at 8 years of age: Taiwan maternal and infant cohort study,” Environmental Health Perspectives, vol. 123, no. 1, pp. 95–100, 2015. View at Publisher · View at Google Scholar · View at Scopus
  29. Q. Shen, H. Shi, Y. Zhang, and Y. Cao, “Dietary intake and phthalates body burden in boys and girls,” Archives of Public Health, vol. 73, no. 1, article 5, 2015. View at Google Scholar · View at Scopus
  30. X. Han, Z. Cui, N. Zhou et al., “Urinary phthalate metabolites and male reproductive function parameters in Chongqing general population, China,” International Journal of Hygiene and Environmental Health, vol. 217, no. 2-3, pp. 271–278, 2014. View at Publisher · View at Google Scholar · View at Scopus