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BioMed Research International
Volume 2016 (2016), Article ID 1376526, 12 pages
http://dx.doi.org/10.1155/2016/1376526
Research Article

Comparison of the Effects of Dibutyl and Monobutyl Phthalates on the Steroidogenesis of Rat Immature Leydig Cells

1Center of Scientific Research, The Second Affiliated Hospital & Yuying Children’s Hospital, Wenzhou Medical University, Wenzhou, Zhejiang 325027, China
2Department of Anesthiology, The Second Affiliated Hospital & Yuying Children’s Hospital, Wenzhou Medical University, Wenzhou, Zhejiang 325027, China
3School of Pharmacy, Wenzhou Medical University, Wenzhou, Zhejiang 325035, China
4Taizhou Hospital of Zhejiang Province, Taizhou 317000, China

Received 3 January 2016; Accepted 17 February 2016

Academic Editor: Stelvio M. Bandiera

Copyright © 2016 Linxi Li et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Supplementary Material

The steroidogenic pathway in rat immature Leydig cells will be shown in the supplementary material. Cholesterol is transported into Leydig cells via lipoprotein (LP)-receptor (SCARB1). When LH binds to luteinizing hormone receptor (LHCGR) to induce LHCGR-complex interaction leading to cAMP cascade, the latter activates protein kinase A, which induces the expression of steroidogenic acute regulatory protein (STAR). STAR is the rate-limiting step to transport intracellular cholesterol into mitochondrial inner membrane.

  1. Supplementary Material