Manipulation of DNA Repair Proficiency in Mouse Models of Colorectal Cancer

Figure 1

Pathology of intestinal lesions in Apc^Min/+ and Blm/BLM mice. (a) Gastrointestinal neoplasia (red box) in Apc^Min/+ mouse intestine; (b) adenoma in Apc^Min/+ mouse intestine (ileum); (c) carcinoma in Apc^Min/+;Blm^Cin/+ mouse intestine; (d) adenoma in Ccsp/fgf-10;Blm^Cin/+ lung tissue; (e) adenoma in Apc^Min/+;BLM^Tg mouse intestine; (f) isolated retinal pigment epithelial (RPE) cells in a p^un/un;BLM^Tg mouse retina; (g) a cluster of RPE cells in a p^un/un;BLM^Tg mouse retina; and (h) adenoma in Apc^Min/+;BLM^Tg;Msh2^Δ7N/Δ7N mouse intestine.

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