Metformin Alleviated Aβ-Induced Apoptosis via the Suppression of JNK MAPK Signaling Pathway in Cultured Hippocampal Neurons

Figure 2

Metformin rescued Aβ- (200 μM) induced hyperphosphorylation of MAPK JNK. (a), (b), and (c) Quantitative analysis of western blot assay showed that Aβ increased the phosphorylation level of JNK, which was reserved by metformin (, ), while there was no significant difference in the phosphorylation level of ERK1/2 or P38 between the experimental groups (, ).

(a)

(b)

(c)