Inhibitor of Nicotinamide Phosphoribosyltransferase Sensitizes Glioblastoma Cells to Temozolomide via Activating ROS/JNK Signaling Pathway

Figure 5

NAMPT inhibitor activates c-Jun/JNK signaling pathway in glioblastoma cells. (a) Representative images of phosphorylation of c-Jun and JNK in TMZ alone, TMZ plus FK866, and TMZ plus CHS828 treated U251-MG GBM cells. (b-c) Quantitative analysis on the phosphorylation of c-Jun and JNK in TMZ alone, TMZ plus FK866, and TMZ plus CHS828 treated U251-MG GBM cells. versus TMZ alone. .

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