Interactions between CYP11B2 Promoter Methylation and Smoking Increase Risk of Essential Hypertension

Table 3

Association of promoter methylation with environmental factors in control.

Variable	Gender			Age		Smoking
	Men	Women		(95% CI)		(95% CI)
CpG1			0.983	0.104 (0.014, 0.194)	0.009	1.949 (−0.362, 4.260)	0.055
CpG2			0.013	−0.003 (−0.123, 0.117)	0.960	−2.215 (−5.250, 0.820)	0.096
CpG3			0.039	−0.047 (−0.128, 0.034)	0.148	−2.485 (−4.551, −0.419)	0.007
CpG4			0.082	−0.051 (−0.215, 0.113)	0.477	−5.089 (−9.254, −0.924)	0.006

was adjusted by logistic regression for age, BUA, smoking, drinking, BMI, ALP, TG, HDL, LDL, and Hcy. was calculated by multiple linear regression model including gender, age, BUA, smoking, drinking, BMI, ALP, TG, HDL, LDL, and Hcy. BMI: body mass index; ALP: alkaline phosphatase; TG: triglycerides; HDL: high-density lipoprotein; LDL: low-density lipoprotein; Hcy: homocysteine.