Interactions between CYP11B2 Promoter Methylation and Smoking Increase Risk of Essential Hypertension

Table 5

Association of promoter methylation with environmental factors in whole participants.

Variable	Gender			Age		Smoking
	Men	Women		(95% CI)		(95% CI)
CpG1			0.181	0.112 (0.062, 0.162)	<0.001	0.742 (−0.640, 2.123)	0.291
CpG2			0.007	0.001 (−0.059, 0.060)	0.983	−0.659 (−2.314, 0.996)	0.433
CpG3			0.405	−0.042 (−0.095, 0.010)	0.115	−0.401 (−2.575, 0.363)	0.139
CpG4			0.323	−0.029 (−0.117, 0.059)	0.520	−2.664 (−5.118, 0.210)	0.034

was adjusted by logistic regression for EH, age, BUA, smoking, drinking, BMI, ALP, TG, HDL, LDL, and Hcy. was calculated by multiple linear regression model including gender, age, BUA, smoking, drinking, BMI, ALP, TG, HDL, LDL, and Hcy. BMI: body mass index; ALP: alkaline phosphatase; TG: triglycerides; HDL: high-density lipoprotein; LDL: low-density lipoprotein; Hcy: homocysteine.