Figure 3: Liver histology of mice infected with 50 or 100 cercariae. Representative images of mice livers (HE, 2.5-fold magnification and SR, 2.5-fold magnification): uninfected mice (naive), mice infected with 50 cercariae (50 cercariae), and mice infected with 100 cercariae (100 cercariae). Livers of mice infected with 100 cercariae have considerably more periocular granulomas compared to the other mice. Higher infection rates result in tortuous vascularization of the portal area and pronounced portoportal bridging with markedly sclerosed hepatic veins.