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BioMed Research International
Volume 2016, Article ID 1579428, 8 pages
http://dx.doi.org/10.1155/2016/1579428
Research Article

Health-Related Quality of Life in Children and Adolescents with Hereditary Bleeding Disorders and in Children and Adolescents with Stroke: Cross-Sectional Comparison to Siblings and Peers

1Department of Anesthesiology and Intensive Care Medicine, Charité-Universitaetsmedizin Berlin, Campus Charité Mitte and Campus Virchow-Klinikum, 10117 Berlin, Germany
2Institute for Medical Psychology, University Medical Center Hamburg-Eppendorf, 20246 Hamburg, Germany
3Department of Pediatric Hematology/Oncology, Charité-Universitaetsmedizin Berlin, Campus Virchow-Klinikum, 13353 Berlin, Germany
4Working Group Cardiovascular Magnetic Resonance, Experimental und Clinical Research Center (ECRC), Charité-Universitaetsmedizin Berlin, Campus Buch, 13125 Berlin, Germany
5Department of Internal Medicine, Angiology and Clotting Disorders, Haemophilia Treatment Centre, Vivantes Clinic Friedrichshain, 10249 Berlin, Germany
6Pediatric Thrombosis and Hemostasis Unit, Dr. von Hauner Children’s Hospital, Medical Center of the University of Munich, 80337 Munich, Germany
7Department of Pediatric Hematology/Oncology, University of Münster, 48149 Münster, Germany
8Coagulation Centre Rhine-Ruhr, 47051 Duisburg, Germany
9Department of Clinical Chemistry, University Hospital Schleswig Holstein, 24105 Kiel, Germany
10Children’s Hospital, Department of Pediatric Oncology and Hematology, 86156 Augsburg, Germany

Received 5 February 2016; Accepted 7 April 2016

Academic Editor: Nick Kontodimopoulos

Copyright © 2016 Bruno Neuner et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Abstract

Objectives. To investigate self-reported health-related quality of life (HrQoL) in children and adolescents with chronic medical conditions compared with siblings/peers. Methods. Group 1 (6 treatment centers) consisted of 74 children/adolescents aged 8–16 years with hereditary bleeding disorders (HBD), 12 siblings, and 34 peers. Group 2 (one treatment center) consisted of 70 children/adolescents with stroke/transient ischemic attack, 14 siblings, and 72 peers. HrQoL was assessed with the “revised KINDer Lebensqualitätsfragebogen” (KINDL-R) questionnaire. Multivariate analyses within groups were done by one-way ANOVA and post hoc pairwise single comparisons by Student’s -tests. Adjusted pairwise comparisons were done by hierarchical linear regressions with individuals nested within treatment centers (group 1) and by linear regressions (group 2), respectively. Results. No differences were found in multivariate analyses of self-reported HrQoL in group 1, while in group 2 differences occurred in overall wellbeing and all subdimensions. These differences were due to differences between patients and peers. After adjusting for age, gender, number of siblings, and treatment center these differences persisted regarding self-worth () and friend-related wellbeing (). Conclusions. In children with HBD, HrQoL was comparable to siblings and peers. In children with stroke/TIA HrQoL was comparable to siblings while peers, independently of relevant confounder, showed better self-worth and friend-related wellbeing.