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BioMed Research International
Volume 2016, Article ID 1627143, 6 pages
Research Article

Matrix Metalloproteinase-9 −1562C/T Gene Polymorphism Is Associated with Diabetic Nephropathy

1Department of Gastroenterology, The First Affiliated Hospital of Jinan University, Guangzhou 510630, China
2Clinical Laboratory, People’s Hospital of New District Longhua, Shenzhen 518109, China
3Department of Nephrology, Affiliated Hospital of Guilin Medical College, Guangxi 541001, China

Received 17 May 2016; Accepted 25 July 2016

Academic Editor: Konstantinos Kantartzis

Copyright © 2016 Shufen Feng et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.


To investigate the association between the metalloproteinase-9 (MMP9) −1562C/T polymorphism and diabetic nephropathy (DN) in Han Chinese, the patients with type 2 diabetes were collected and divided into the non-DN (NDN) and DN groups; controls were recruited. Genotype and allele frequencies were assessed using polymerase chain reaction and restriction fragment length polymorphism. Results showed that SBP, DBP, HbA1c, UAER, Cr, BUN, TG, and TC were higher in the DN group compared with the control and NDN groups. SBP, HbA1c, and TC in DN patients with the TT and CT genotypes were lower than in those with CC. Compared with controls, the frequency of the T allele in the DN group was significantly lower. The MMP9 −1562C allele, SBP, Cr, BUN, TG, and TC were independent risk factors for DN. All of the above suggested that the MMP9 −1562C/T polymorphism was associated with DN in Han Chinese.