Secondary Focal Segmental Glomerulosclerosis: From Podocyte Injury to Glomerulosclerosis

Figure 1

Rearrangement of actin cytoskeletons. (a) Podocyte foot processes and actin cytoskeletons in physiologic condition. (b) Actin cytoskeletons are rearranged into dense network at the basal area of foot process with effacement. (c) Actin-rich center (ARC) is formed within the dense network of actin cytoskeleton to maintain the network. Microfilaments are connected between basal side of foot process and lamina densa (LD) of glomerular basement membrane.

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