Rapid Identification of Potential Drugs for Diabetic Nephropathy Using Whole-Genome Expression Profiles of Glomeruli
Table 1
The baseline clinical and pathologic characteristics of DN patients.
Early stage
Late stage
6
12
—
Age (years)
45.9 ± 6.4
51.0 ± 6.8
0.103
Sex (female, %)
3 (50%)
3 (25%)
0.344
Ethnicity
Han
Han
—
BMI (kg/m2)
25.3 ± 1.5
24.9 ± 1.3
0.892
Serum creatinine (mg/dL)
0.63 ± 0.13
2.34 ± 0.74
0.000
eGFR (mL/min)
112.8 ± 8.1
32.9 ± 13.3
0.000
Proteinuria (g/24 h)
0.82 ± 0.47
5.18 ± 2.01
0.000
HbA1C (%)
8.4 ± 1.6
7.2 ± 1.9
0.146
BUN (mg/dL)
15.4 ± 4.8
35.8 ± 11.8
0.003
Glomerular lesions
0.000
Class I
3
0
Class IIa
3
0
Class IIb
0
0
Class III
0
7
Class IV
0
5
IFTA
0.006
0
2
0
1
4
2
2
0
4
3
0
6
Interstitial inflammation
0.004
0
2
0
1
3
1
2
1
11
Arteriolar hyalinosis
0.333
0
0
0
1
1
0
2
5
12
Arteriosclerosis
0.504
NA
0
0
0
2
1
1
1
2
2
3
9
BMI: body mass index; eGFR: estimated glomerular filtration rate, calculated using the EPI-CKD formula; HbA1C: glycated hemoglobin; BUN: blood urea nitrogen. Values are presented as or means ± SD. values were obtained using the Wilcoxon rank sum test for continuous variables and Fisher’s exact test for categorical variables.
