Rapid Identification of Potential Drugs for Diabetic Nephropathy Using Whole-Genome Expression Profiles of Glomeruli

Table 2

The baseline clinical and pathologic characteristics of DN patients for validation.

	Early stage	Late stage
	5	4	—
Age (years)	43.1  ± 11.8	52.1  ± 7.3	0.226
Sex (female, %)	3 (60%)	2 (50%)	1
Ethnicity	Han	Han	—
BMI (kg/m^2)	25.5  ± 4.7	22.9  ± 2.3	0.342
Serum creatinine (mg/dL)	0.65  ± 0.15	1.76  ± 0.54	0.003
eGFR (mL/min)	112.3  ± 4.3	42.1  ± 17.4	0.000
Proteinuria (g/24 h)	0.50  ± 0.23	4.43  ± 0.41	0.000
HbA1C (%)	6.5  ± 0.9	7.3  ± 1.0	0.285
BUN (mg/dL)	14.2  ± 2.7	30.0  ± 6.8	0.002
Glomerular lesions			0.016
Class I	1	0
Class IIa	4	0
Class IIb	0	0
Class III	0	2
Class IV	0	2
IFTA			0.087
0	1	0
1	4	1
2	0	3
3	0	0
Interstitial inflammation			0.286
0	1	0
1	4	2
2	0	2
Arteriolar hyalinosis			1
0	0	0
1	0	0
2	5	4
Arteriosclerosis			1
NA	0	0
0	1	0
1	2	1
2	2	3