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BioMed Research International
Volume 2016, Article ID 1691579, 5 pages
http://dx.doi.org/10.1155/2016/1691579
Research Article

Preparation and In Vivo Pharmacokinetics of the Tongshu Suppository

1Department of Pharmacy, The Third Hospital of Hebei Medical University, Shijiazhuang 050051, China
2The Third Hospital of Hebei Medical University, Shijiazhuang 050051, China

Received 28 April 2016; Accepted 19 July 2016

Academic Editor: Sanjula Baboota

Copyright © 2016 Guoqiang Liu et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Abstract

Astragalus polysaccharide (APS) (used for intestinal protection) was added to formulate the Tongshu suppository to improve the pharmacokinetics of Aceclofenac, which were assessed in New Zealand rabbits using an orthogonal experimental design. The single-agent Aceclofenac was taken as the control formulation. The concentration-time and drug release curves were drawn, and (min), (μg·mL−1), , and MRT were compared using a pharmacokinetic systems program. The formulated Tongshu suppository had moderate hardness, a smooth surface with uniform color, and theoretical drug-loading rate of 8%. Its release rate was in accordance with the drug preparation requirements. The concentration-time curves and drug release curves revealed that the maximum concentrations () were μg·mL−1 and μg·mL−1 for the Tongshu and Aceclofenac suppositories, respectively, showing statistically insignificant difference, while the peak times were  min and  min, respectively, also showing statistically insignificant difference. Compared with the Aceclofenac suppository, the relative bioavailability of the Tongshu suppository was 104.4%, and the difference between them was statistically insignificant. In this experiment, the Tongshu suppository was prepared using the hot-melt method. In vivo pharmacokinetic studies confirmed it had higher bioavailability than the Aceclofenac suppository.