Tumor Take Rate Optimization for Colorectal Carcinoma Patient-Derived Xenograft Models

Figure 3

Depicted are the two successfully established cell lines form this series in passage number 1. Two different areas are displayed to demonstrate the minor morphological differences. (a) HROC107. Note the hem of obviously dying cells in the upper left picture. In the colony center (also of the lower left picture), a population of cells with a copper-stone phenotype can be found which dominated the culture in subsequent passages. (b) HROC131. Similar to HROC107, areas with a larger cell type can be observed in the upper right picture. Smaller cells (displayed in the lower right picture), again with a copper-stone phenotype, took over in the culture in later passages, too.

(a)

(b)