(a)
(b)
(c)
(d)
(e)
Figure 3: Emodin did not alter protein expression levels of calpain 1 but did increase calpain 1 activity and alter the expression levels of cleaved fragments of caspases 12 and 3. (a) Calpain 1 activity was different in each group. It was decreased in rats with SAP and was increased in emodin-treated rats. PD150606 attenuated this effect of emodin. ((b), (c), (d), and (e)) Each group showed a comparable level of calpain 1 protein expression. However, the levels of cleaved fragments of caspases 12 and 3 were different in each group. They were decreased in the SAP group and increased in the EM group. PD150606 attenuated this effect of emodin. versus SO. versus SAP. and versus EM.