Mitochondria Biogenesis and Bioenergetics Gene Profiles in Isogenic Prostate Cells with Different Malignant Phenotypes

Table 2

Top five canonical pathways associated with differentially expressed genes between RC77T/E and RC77N/E.

#	Ingenuity canonical pathways		Ratio	Molecules
1	Mitochondrial dysfunction			UCP2, RHOT2, NDUFS7, ATP5G1, ATP5F1, SOD2, ATP5L, NDUFB6, NDUFA8, UQCRQ, NDUFS5, NDUFV2, ATP5G3
2	Oxidative phosphorylation			ATP5L, NDUFB6, NDUFA8, UQCRQ, ATP5G1, NDUFS7, ATP5F1, NDUFS5, NDUFV2, ATP5G3
3	Superoxide radicals degradation			SOD2, SOD1
4	Amyotrophic lateral sclerosis signaling			SOD1, BCL2L1, BID, NEFL
5	Apoptosis signaling			BCL2L1, BID, BAK1
6	Molecular mechanisms of cancer			RHOT2, CDKN2A, BCL2L1, BID, BAK1
7	Docosahexaenoic acid (DHA) signaling			BCL2L1, BID
8	Aldosterone signaling in epithelial cells			HSPA1A/HSPA1B, HSPD1, HSP90AA1
9	Myc mediated apoptosis signaling			CDKN2A, BID
10	PEDF signaling			SOD2, BCL2L1