Research Article
Nicotinamide Mononucleotide Adenylyl Transferase 2: A Promising Diagnostic and Therapeutic Target for Colorectal Cancer
Table 3
Comparison of positive expression of NMNAT2 and p53 between different clinical pathological characteristic groups of colorectal cancer.
| | Parameters | Patients () | NMNAT2 | p53 | | Negative | Positive | value | Negative | Positive | value |
| | Gender | | | | | | | | | Male | 50 | 9 (18.0%) | 41 (82.0%) | | 18 (36.0%) | 32 (64.0%) | | | Female | 45 | 8 (17.8%) | 37 (82.2%) | 17 (37.8%) | 28 (62.2%) | | Age | | | | | | | | | ≥65 | 51 | 6 (11.8%) | 45 (88.2%) | | 18 (35.3%) | 33 (64.7%) | | | <65 | 44 | 11 (25.0%) | 33 (75.0%) | 17 (38.6%) | 27 (61.4%) | | Morphology | | | | | | | | | Ulcerative type | 65 | 12 (18.5%) | 53 (81.5%) | | 26 (40.0%) | 39 (60.0%) | | | Polypoid type | 30 | 5 (16.7%) | 25 (83.3%) | 9 (30.0%) | 21 (70.0%) | | Histological type | | | | | | | | | Adenocarcinoma | 77 | 13 (16.9%) | 64 (83.1%) | | 29 (37.7%) | 48 (62.3%) | | | Mucous carcinoma | 18 | 4 (22.2%) | 14 (77.8%) | 6 (33.3%) | 12 (66.7%) | | Differentiation | | | | | | | | | Well | 21 | 3 (14.3%) | 18 (85.7%) | | 10 (47.6%) | 11 (52.4%) | | | Middle and poor | 74 | 14 (18.9%) | 60 (81.1%) | 25 (33.8%) | 49 (66.2%) | | Average diameter | | | | | | | | | ≥3 | 52 | 8 (15.4%) | 44 (84.6%) | | 17 (32.7%) | 35 (67.3%) | | | <3 | 43 | 9 (20.9%) | 34 (79.1%) | 18 (41.9%) | 25 (58.1%) | | Depth of invasion | | | | | | | | | T1 + T2 | 44 | 13 (29.5%) | 31 (70.5%) | | 25 (56.8%) | 19 (43.2%) | | | T3 + T4 | 51 | 4 (7.8%) | 47 (92.2%) | 10 (19.6%) | 41 (80.4%) | | Lymph metastasis | | | | | | | | | N0 | 60 | 14 (23.3%) | 46 (76.7%) | | 28 (46.7%) | 32 (53.3%) | | | N1 + N2 | 35 | 3 (8.6%) | 32 (91.4%) | 7 (20.0%) | 28 (80.0%) | | TNM stage | | | | | | | | | I + II | 56 | 14 (25.0%) | 42 (75.0%) | | 26 (46.4%) | 30 (53.6%) | | | III + IV | 39 | 3 (7.7%) | 36 (92.3%) | 9 (23.1%) | 30 (76.9%) |
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