Table 2: Exercise interventions in rodents.

ReferenceStudy designStudy populationTreatmentType of exerciseDurationParameters

Chemotherapy
Winocur et al., 2014 [33]38 
9 MTX/5FU Run 
10 MTX/5FU 
9 CG Run 
9 CG
2 × 2 
RCT
f, Long-Evans rats37.8 mg/kg MTX + 50 mg/kg 5FU or salt solutionAccess to a running wheel11 weeksSM () 
CM () 
NMTS () 
DNMTS () 
Hippocampal neurogenesis ()
Fardell et al., 2012 [34]28 
7 5FU/OX Run 
7 5FU/OX 
7 CG Run 
7 CG
2 × 2 
RCT
m, hooded Wistar rats75 mg/kg FU + 8 mg/kg OX or salt solutionAccess to a running wheel overnight6 weeksNOR () 
MWM ()

Cranial radiation
Ji et al., 2014 [32]104 
16 20 Gy Run 
16 20 Gy 
16 CG Run 
16 CG
2 × 2 
RCT
Sprague-Dawley rats20 Gy or sham radiation30 min access to a running wheel in the morning and evening5x/week over 3 weeksOpen-field test () 
MWM () 
BDNF () 
Hippocampal neurogenesis ()
Wong-Goodrich et al., 2010 [35]40 
10 5 Gy Run 
10 5 Gy 
10 CG Run 
10 CG
2 × 2 
RCT
f, C57BL/6 mice5 Gy or sham radiationAccess to a running wheel 8/12 hours per day16 weeksBarnes Maze () 
Hippocampal neurogenesis () 
Growth factor expression ()
Naylor et al., 2008 [36]16 
4 6 Gy Run 
4 6 Gy 
4 CG Run 
4 CG
2 × 2 
RCT
C57BL/6 mice6 Gy or sham radiationAccess to a running wheel4 weeksOpen-field test () 
Hippocampal neurogenesis ()

5FU: 5-Fluorouracil; OX: Oxaliplatin; CG: control group; Gy: Gray; RCT: Randomized Controlled Trial; m: male; f: female; NOR: Novel Object Recognition; MWM: Morris Water Maze; SM: spatial memory; CM: Cued Memory; NMTS: Non-Matching to Sample Task, DNMTS: Delayed Non-Matching to Sample task.