Research Article

Expression Profiling of Genes Related to Endothelial Cells Biology in Patients with Type 2 Diabetes and Patients with Prediabetes

Table 3

Direct comparison of gene expression levels between groups 1 and 2.

GeneDescriptionFold changes95% CI

ADAM17ADAM metallopeptidase domain 171.1313(0.00001, 2.49)
ALOX5Arachidonate 5-lipoxygenase1.7179(0.85, 2.59)
APOEApolipoprotein E2.2932(1.15, 3.44)
EDN2Endothelin 21.7589(0.24, 3.28)
EDNRAEndothelin receptor type A1.8643(0.97, 2.76)
FGF1Fibroblast growth factor 1 (acidic)0.6051(0.44, 0.77)
FLT1Fms-related tyrosine kinase 11.5347(1.04, 2.03)
FN1Fibronectin 115.6273(0.00001, 34.83)
IL11Interleukin 112.4116(1.37, 3.45)
IL1BInterleukin 1, beta1.5735(0.93, 2.22)
IL3Interleukin 372.3372(0.00001, 194.69)
MMP2Matrix metallopeptidase 21.5101(0.52, 2.50)
MMP9Matrix metallopeptidase 93.2641(1.58, 4.95)
NOS3Nitric oxide synthase 3 (endothelial cell)2.1347(1.37, 2.90)
PECAM1Platelet/endothelial cell adhesion molecule2.4771(1.67, 3.28)
PLAUPlasminogen activator, urokinase2.1278(1.14, 3.11)
PTGISProstaglandin I2 (prostacyclin) synthase0.4289(0.23, 0.63)
SELLSelectin L1.4594(0.90, 2.02)
THBDThrombomodulin1.8336(1.19, 2.48)
TYMPThymidine phosphorylase0.4013(0.13, 0.67)

Group 1: patients with type 2 diabetes; Group 2: patients with prediabetes.
95% confidence interval.