The Role of BRCA2 Mutation Status as Diagnostic, Predictive, and Prognosis Biomarker for Pancreatic Cancer

Figure 2

Transformation model of familiar pancreatic adenocarcinoma. Ingoing arrows concern oncogenic effectors that are acquired in the cancer progression. Outgoing arrows highlight tumour suppressor factors that become inactivated in pancreatic cancer. PanIN: pancreatic intraepithelial neoplasia; CIN: chromosome instability; LOH: loss of heterozygosity.