Tropisetron Protects Against Acetaminophen-Induced Liver Injury via Suppressing Hepatic Oxidative Stress and Modulating the Activation of JNK/ERK MAPK Pathways

Figure 6

Survival analysis of APAP-induced liver injury in mice. Mice were intraperitoneally treated with 0.9% normal saline, with APAP 300 mg/kg alone, or with a 3 mg/kg concentration of tropisetron at 30 min before APAP injection. (a) The survival rate was measured until 96 h after normal saline or APAP 300 mg/kg administration (/each group). (b) All animals were sacrificed at 96 h after administration for assay of serum ALT.

(a)

(b)