Heteroreceptors Modulating CGRP Release at Neurovascular Junction: Potential Therapeutic Implications on Some Vascular-Related Diseases

Figure 4

Cellular mechanisms involved in the CGRP-induced vasodilation. The vasodilation induced by α-CGRP is mediated by activation of the CGRP receptor, a seven-transmembrane domain receptor coupled generally to a G_s protein that under activation induces the activity of adenylate cyclase. The α-CGRP induce vasodilation by two mechanisms: a direct effect on the smooth vascular muscle (a) and by endothelial-dependent mechanism (b).