Uncovering Driver DNA Methylation Events in Nonsmoking Early Stage Lung Adenocarcinoma

Figure 1

Schematic overview of the pipeline proposed in this work. (a) Candidate gene selection. Methylation matrix of continuous beta values is converted into difference matrix and discretized by kernel distribution function, which partition samples into normal, T-DM, and T-NDM. Probes are mapped to genes after noise filtering and genes passing the consistent test are collected as candidate driver genes. (b) For each candidate gene, a subset of DM responsive genes is collected and DM responsive modules are constructed by the CLR method. Candidate driver genes are ranked by differential scores derived on the differential network analysis.

(a) Candidate selection

(b) Driver prioritization